Ttc9a
WebSep 6, 2024 · It is plausible therefore that TTC9A negatively regulates ERalpha activity through interacting with co-chaperone proteins such as FKBP38 and FKBP51. TTC9A acts as a chaperone protein to facilitate the function of tropomyosins (including Tm5NM-1) in stabilizing microfilament and it may play a role in cancer cell invasion and metastasis Webstudies in TTC9A knockout (TTC9A−/−) mice have indicated that TTC9A negatively regulates the action of estrogen. In this study we investigated the role of TTC9A on …
Ttc9a
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WebAug 12, 2008 · TTC9A (1–100), which contains the first TPR domain, interacted with Tm5NM-1 to some extent but the interaction was weaker than TTC9A (1–115). Since the first TPR domain lies in residues 57–90, it is plausible that the first TPR domain is required for the interaction. WebFeb 10, 2024 · This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and privacy notice and
WebTTC9A deficient mammary gland showed significant increase in mammary ductal elongation and branching on estrogen and progesterone treatment, demonstrating … WebSep 14, 2012 · TTC9A was induced by mitogens, estrogen and growth factors in breast cancer cells MCF-7 [2]. TTC9A expression is also significantly higher in breast cancer tissues than the adjacent normal tissues [17]. These indicate that TTC9A expression is positively associated with cell proliferation and the presence of growth-stimulating signals.
WebThe involvement of tetratricopeptide repeat domain 9A (TTC9A) deficiency in anxiety-like responses and behavioral despair through estradiol action on the serotonergic system … WebThe involvement of tetratricopeptide repeat domain 9A (TTC9A) deficiency in anxiety-like responses and behavioral despair through estradiol action on the serotonergic system has been reported. Emerging evidence suggests that estradiol is a potent modulator of neuroplasticity. As estradiol and neurop …
WebLi Quan, Wing Shan Yu, Smeeta Shrestha, Yu Zuan Or, Thomas Lufkin, Ying-Shing Chan, Valerie CL Lin and Lee Wei Lim (2024) TTC9A deficiency induces estradiol-mediated …
WebSep 14, 2012 · 1. Introduction. Tetratricopeptide repeat domain 9A (TTC9A) is a member of TTC9 family proteins that also include TTC9B and TTC9C. Human TTC9A gene was first identified by sequence analysis of a cDNA clone from a brain cDNA library .It was confirmed to code for a 222 amino acid TTC9A protein in human using mouse polyclonal antibody … the partyka brass quintetWebAnti-TTC9 antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution; Synonyms: Anti … shwashwi gossipWebEmerging evidence suggests that estradiol is a potent modulator of neuroplasticity. As estradiol and neuroplasticity changes are both implicated in mood regulation, and estradiol activity is negatively regulated by TTC9A, we hypothesized that the behavioral changes induced by Ttc9a-/- is also mediated by neuroplasticity-related mechanisms. the party is to be heldWebApr 1, 2024 · Since Ttc9a is induced by estrogen in estrogen target tissues, these results suggest that Ttc9a is a negative regulator of estrogen function through a negative … shwash lightingWebDownload scientific diagram Truncation constructs of TTC9A protein and their relative binding to Tm5NM-1 based on co-immunoprecipitation experiment. from publication: … shwashwi latest gossipWebApr 1, 2024 · In brief, Ttc9a-/-and wildtype female mice were subjected to ovariectomy (OVX) as reported (Lim et al., 2016; Lin et al., 2001). After a 10-day recovery period, mice were administered a subcutaneous injection of either 10 μg/kg 17-β-estradiol benzoate . Effects of Ttc9a-/-and estradiol modulation on tail suspension immobility shwas homes vyttilaWebEmerging evidence suggests that estradiol is a potent modulator of neuroplasticity. As estradiol and neuroplasticity changes are both implicated in mood regulation, and … shwas hospital latur