Dicarboxypropylation
WebDec 30, 2024 · In the cytosol, itaconate alkylates KEAP1, a novel PTM termed 2,3-dicarboxypropylation, and GSH to form an itaconate-GSH adduct, or 2,3-dicarboxypropyl-GSH (4). This in turn activates the anti ... WebJun 15, 2024 · The unsaturated dicarboxylic acid structure of itaconate renders it slightly electrophilic and mediates an interaction with thiol functional groups through 2, 3-dicarboxypropylation in the cytosol (Hooftman et al., 2024; Peace and O’Neill, 2024). Itaconate has anti-inflammatory and anti-oxidant properties that have been partly …
Dicarboxypropylation
Did you know?
WebDicarboxylic acids are organic compounds that contain two functional carboxylic acid (–COOH) groups. Industrially, they are important in production of polyester, polyols, … WebApr 1, 2024 · Further characterization of the immunometabolic crosstalk can provide insight to chronic infection and persistence of intracellular pathogens. In addition to its role in supplying energy demands ...
WebMar 1, 2024 · Chemoproteomic profiling of the itaconate modification 2,3-dicarboxypropylation (or “itaconation”) in macrophages found that JAK1 is modified … WebApr 1, 2024 · In addition, 4-octyl itaconate (OI), an itaconate derivative, can modulate NLRP3 activation by inhibiting the interaction of NLRP3 with NEK7 through dicarboxypropylation of C548 on NLRP3 [68]. By contrast, another study suggested that itaconate confers tolerance to NLRP3 activation by acting downstream of ASC speck …
WebMay 12, 2024 · Itaconate could abolish NLRP3-NEK7 connection in a modification termed dicarboxypropylation on C548 of NLRP3. They also observed that 4-OI … WebMar 28, 2024 · Itaconate alkylates cysteine residues 151, 257, 288, 273 and 297 on the protein KEAP1, enabling Nrf2 to increase the expression of downstream genes with anti-oxidant and anti-inflammatory ...
WebMar 10, 2024 · Succination (b) and 2,3-dicarboxypropylation (c) are modifications caused by a nonenzymatic reaction between a cysteine residue in a protein, or a low-molecular-weight thiol (e.g., GSH), and fumarate or itaconate, respectively. No reactions reversing those two cysteine adducts have been described occurring in cells. Overall, these …
WebDec 30, 2024 · In the cytosol, itaconate alkylates KEAP1, a novel PTM termed 2,3-dicarboxypropylation, and GSH to form an itaconate-GSH adduct, or 2,3 … chillox bananiWebFeb 1, 2024 · This is particularly the case with more electrophilic derivatives, such as 4OI. Examples of dicarboxypropylation by ITA include JAK1 that inhibits M2 macrophage polarization [18] and several glycolytic enzymes, including aldolase and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and the pyroptosis regulator Gasdermin D 17, 19, 20. grace tv show channel 7WebInfobox references. Dipropyl peroxydicarbonate (trade name Luperox 221) is an organic peroxide with a variety of industrial uses, particularly as an initiator of polymerization. [1] … chillox near meWebJul 20, 2024 · These NLRP3 modifications include SUMOylation [163,164,165], nitrosylation [166,167,168], alkylation [169,170], acetylation , and dicarboxypropylation, which is a rare modification mediated by 4-octyl itaconate, a derivative of immunomodulatory metabolite itaconate [172,173]. Collectively, phosphorylation and various PTMs are critical ... chillox mymensinghWebAug 12, 2024 · This form of cysteine alkylation, termed 2,3-dicarboxypropylation or itaconation, has been shown to be an important part of the anti-inflammatory properties … chillox wariWebIn the cytosol, itaconate alkylates KEAP1, a novel PTM termed 2,3-dicarboxypropylation, and GSH to form an itaconate-GSH adduct, or 2,3-dicarboxypropyl-GSH. This in turn activates the anti-inflammatory and anti-oxidant transcription factor Nrf2 and ATF3. Levels of the metabolite 2,3-dicarboxypropyl cysteine (Itaconate-cysteine adduct) increase ... grace tyersWebJul 20, 2024 · A new post-translational modification – called 2,3-dicarboxypropylation - occurs on cysteines of KEAP1 in human and murine macrophages treated with the … chillox website